呂劍，博士，講師，碩士生導師
地址： 湖北省武漢市東湖新技術開發區光谷一路206号
郵編：430205
E-mail: 1020224140@qq.com
教育背景
2015/09–2021/06，華中科技大學，有機化學，博士 （導師：董海 教授）
2011/09–2015/06，安陽工學院，化學工程與工藝，學士
工作履曆
2023/01–至今，77779193永利官网，77779193永利官网，講師
2021/06–2022/12，南洋理工大學，博士後（合作導師：劉學偉 教授）
研究領域
糖羟基的選擇性功能化；糖苷鍵的高效構建
糖藥物分子的設計與合成
科研項目
1. 77779193永利官网科研啟動基金，糖羟基磷酸化的位點/區域選擇性研究(23QD37)，10萬元，主持；
2. 生物無機化學與藥物湖北省重點實驗室開放基金，基于選擇性磷酰化策略的空腸彎曲杆菌81-176夾膜寡糖片段合成研究(BCMM202405)，2萬元，主持。
學術成果
代表性論文：
[1] Jie Zhao, Xiaorui Zhang, Qichang Yang, Haifeng Wang, Shuang-Xi Gu, Qiongjiao Yan, Jian Lv*, Fen-Er Chen*. Synthesis of Deoxy Pyranosides Via Fe(III) Catalyzed Regioselective Thiocarbonylation of Partially Protected Carbohydrates. Eur. J. Org. Chem., 2024, e202400512.
[2] Han Ding, Jian Lv (co-first author), Xiao-Lin Zhang, Yuan Xu, Yu-Han Zhang, Xue-Wei Liu*. Efficient O- and S-glycosylation with ortho-2,2- dimethoxycarbonylcyclopropylbenzyl thioglycoside donors by catalytic strain-release. Chem. Sci., 2024, 15, 3711−3720.
[3] Han Ding, Jian Lyu, Xiao-Lin Zhang, Xiong Xiao, Xue-Wei Liu*. Efficient and versatile formation of glycosidic bonds via catalytic strain-release glycosylation with glycosyl ortho−2,2- dimethoxycarbonylcyclopropylbenzoate donors. Nat. Commun., 2023, 14, 4010−4021.
[4] Jian Lv, Chun-Yang Liu, Yang-Fan Guo, Guang-Jing Feng, Hai Dong*. SnCl2-Catalyzed Acetalation/Selective Benzoylation Sequence for the Synthesis of Orthogonally Protected Glycosyl Acceptors. Eur. J. Org. Chem., 2022, e202101565.
[5] Jian Lv, Jian-Cheng Yu, Guang-Jing Feng, Tao Luo, Hai Dong*. Stannous chloride as a low toxicity and extremely cheap catalyst for regio-/site-selective acylation with unusually broad substrate scope. Green Chem., 2020, 22, 6936−6942.
[6] Jian Lv, Yu Liu, Jia-Jia Zhu, Dapeng Zou, Hai Dong*. Regio/Site-Selective Alkylation of Substrates Containing the Cis-, 1,2- or 1,3-Diol with Ferric Chloride and Dipivaloylmethane as the Catalytic System. Green Chem., 2020, 22, 1139−1144.
[7] Jian Lv, Jia-Jia Zhu, Yu Liu, Hai Dong*. Regioselective Sulfonylation/Acylation of Carbohydrates Catalyzed by FeCl3 Combined with Benzoyltrifluoroacetone and Its Mechanism Study. J. Org. Chem., 2020, 85, 3307−3319.
[8] Jian Lv, Tao Luo, Dapeng Zou, Hai Dong*. Using DMF as Both a Catalyst and Cosolvent for the Regioselective Silylation of Polyols and Diols. Eur. J. Org. Chem., 2019, 2019, 6383–6395.
[9] Jian Lv, Jian-Tao Ge, Tao Luo, Hai Dong*. An inexpensive catalyst, Fe(acac)3, for regio/site-selective acylation of diols and carbohydrates containing a 1,2-cis-diol, Green Chem., 2018, 20, 1987−1991.
[10] Jian Lv, Tao Luo, Ying Zhang, Zhichao Pei*, Hai Dong*. Regio/Site-Selective Benzoylation of Carbohydrates by Catalytic Amounts of FeCl3. ACS Omega, 2018, 3, 17717−17723.
