龍思會，博士，教授

地址：中國.湖北.武漢.東湖新技術開發區光谷一路206号，77779193永利官网

郵編：430205

Email：sihuilong@wit.edu.cn; 1738054890@qq.com

電話：17762502329

教育背景

2000 - 2006 美國肯塔基大學化學系（Department of Chemistry, University of Kentucky），博士

1997 - 2000 武漢大學化學系，碩士

1993 – 1997 武漢大學化學系，學士

工作履曆

2014.1- 77779193永利官网，特聘教授, 教授

2012-2013 美國俄亥俄州立大學化學與生物化學系(Department of Chemistry and Biochemistry, Ohio State University) 博士後

2011-2012 美國俄亥俄州立大學藥學院(College of Pharmacy, Ohio State University) 博士後

2006-2011 美國肯塔基大學藥學院 (College of Pharmacy, University of Kentucky) 博士後

學術兼職

美國化學會（ACS）和美國藥劑科學家協會（AAPS）會員

研究領域

藥物化學：抗腫瘤藥物的設計，合成(design, synthesis and evaluation of anticancer drugs)；抗生素類藥物的設計，合成(design, synthesis and evaluation of antibiotics)；天然多肽的模拟(peptidomimicry)

藥物制劑：藥物分子的多晶型(polymorphism of APIs）,預制劑(preformulation), 藥物輸送體系(drug delivery systems)

有機化學：有機合成(organic synthesis)

代表性論文（專利，專著）

2025

Chen, H.; Zhang, B.; Chen, S.; Xiong, F.; Zhu, X.; Yu, B.; Long, S. “Recent advances in transition metal-mediated/catalyzed radiofluorination of arenes and heteroarenes for positron emission tomography” Bioorganic Chemistry 2025 ASAP

Rehman, M. U.; Zuo, Y.; Tu, N.; Guo, J.; Liu, Z.; Cao, S.; Long, S. “Diverse pharmacological activities of β-carbolines: Substitution patterns, SARs and mechanisms of action” European Journal of Medicinal Chemistry 2025, 287, 117350

Rehman, M. U.; He, F.; Shu, X.; Guo, J.; Liu, Z.; Cao, S.; Long, S. “Antibacterial and antifungal pyrazoles based on different construction strategies” European Journal of Medicinal Chemistry 2025, 282, 117081

2024

Gao, Y.; Cui, J.; Cao, S.; Guo, J.; Liu, Z.; Long, S. “Recent advances in peptoids as promising antimicrobial agents to target diverse microbial species” European Journal of Medicinal Chemistry 2024, 280, 116982

Cui, J.; Gao, W.; Liu, Z.; Cao, S.; Long, S. “Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs” European Journal of Medicinal Chemistry Reports 2024, 12, 100221

Rehman, M. U.; Long, S. “Progress and challenges in the development of triazole antimicrobials” Future Medicinal Chemistry 2024,16(23), 2451-2453

Li, J.; Li, X.; Wu, K.; Long, S.; Zhao, Y.; Jin, X.; Zhang, M.; Wu, X.; Huang, Z.; Zhou, Z.; Liu, J.; Liu, B. ”Predicting Drug‑Drug Interactions Involving Rifampicin Using a Semi‑mechanistic Hepatic Compartmental Model” Pharmaceutical Research 2024, 41, 699-709

Liu, C.; Chen, H.; Cao, S.; Guo, J.; Liu, Z.; Long, S. “RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective”, Bioorganic Chemistry 2024, 143, 107044

2023

Zhu, J.; Dai, Q.; Zhu, R.; Long, S.; Yu, W. “Advances in research on drugs for treatment of COVID-19”, Progress in Pharmaceutical Sciences 2023, 47(7), 519-531

Hu, Y.; Liu, Z.; Zha, G.; Long, S.; Sridhara, M. B.; Kumar, K. S. S.; Rakesh, K. P. “Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) study” Process Biochemistry 2023, 135, 102–118

86. Gao, W.; Li, Y.; Zhoujin, Y.; Zeng, Q.; Fang, L.; Parkin, S.; Li, T.; Ruan, S.; Long, S. “A peptoid-like approach led to lactam-lactam dimer formation in 2-hydroxy-N-alkyl-N-phenyl-nicotinamides and their polymorphism and solvatomorphism” ACS Omega, 2023, 8, 45447−45456

Wang, J.; Long, S.; Liu, Z.; Rakesh, K. P.; Verma, R.; Verma, S. K.; Kumar, K. S. S. “Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity” Process Biochemistry 2023, 132, 13-29

Chen, S.; Cui, J.; Chen, H.; Yu, B.; Long, S. “Recent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation techniques” European Journal of Medicinal Chemistry, 2023, 262, 115911

Liu, X.; Cui, J.; Zeng, Q.; Fang, L.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Ruan, S.; Long, S. “Solvatomorphism and first-time observation of acid-acid catemer in 4-phenylamino-benzoic acids” RSC Advances, 2023, 13, 21021-21035

Tian, G.; Song, Q.; Liu, Z.; Guo, J.; Cao, S.; Long, S. “Recent advances in 1,2,3- and 1,2,4-triazole hybrids as antimicrobials and their SAR: A critical review” European Journal of Medicinal Chemistry, 2023,259, 115603

Zhu, J.; Chen, S.; Liu, Z.; Guo, J.; Cao, S.; Long, S. “Recent advances in anticancer peptoids” Bioorganic Chemistry 2023, 139, 106686

Li, Y.; Tao, Y.; Zhoujin, Y.; Zhao, F.; Liang, P-Y.; Parkin, S.; Li, T.; Zhou, P-P.; Long, S “π–π stacking in the polymorphism of 2-(naphthalenylamino)-nicotinic acids and a comparison with their analogues” CrystEngComm, 2023, 25, 432–443

Zhoujin, Y.; Li, Y.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. “anti/gauche Conformations lead to the polymorphism in homologous phenylalkylamino-nicotinic acids” Crystal Growth & Design 2023, 23, 3154-3163

2022

Li, J.; Wu, K.; Li, X.; Long, S.; Zhou, Z.; Zhao, Y.; Jia, R.; Song, P.; Liu, J.; Liu, B. “Quantifying induction/inhibition effects on fuzuloparib using a Physiologically Based Pharmaco-Kinetic (PBPK) model” Journal of Clinical and Experimental Pathology 2022, 105(1), 229

Zhu, R.; He, Q.; Li, Z.; Ren, Y.; Liao, Y.; Zhang, Z.; Dai, Q.; Wan, C.; Long, S.; Kong, L.; Fan, W.; Yu, W. “ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy” Acta Biomaterialia, 2022, 153(22), 442

Zhao, X.; Liu, Z.; Liu, H.; Guo, J.; Long, S. “Hybrid molecules based on caffeic acid as potential therapeutics: A focused review” European Journal of Medicinal Chemistry, 2022, 243, 114745

Zhoujin, Y.; Li, Y.; Liang, P.-Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. “Effect of homologation on the polymorphism of anthranilic acids”, Crystal Growth & Design, 2022, 22(10), 6207

Dong, B.; Liu, Y.; Yang, P.; Sang, D.; Tian, J.; Li, L.; Long, S. “Denitrogenative cleavage of benzotriazoles and benzotriazinones, and selective N-desulfonylation of benzotriazoles by aluminum halides”, Tetrahedron Letters, 2022, 103,153965

Xie, D.; Xu, X.; Long, S.; Tang, X-Y.; Wang, L. “Synthesis of (2-(quinolin-2-yl)phenyl)carbamates by a one-pot Friedel-Crafts reaction/oxidative Umpolung Aza-Grob Fragmentation sequence” J. Org. Chem. 2022, 87(12), 7852

Tao, Y.; Liu, X.; Zhoujin, Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Guo, J.; Yu, F.; Long, S. “Conformational flexibility and substitution pattern lead to polymorphism of 3-methyl-2-(phenylamino)benzoic acid” CrystEngComm, 2022, 24, 3217

Zhoujin, Y.; Li, Y., Zhang, M.; Parkin, S.; Guo, J.; Li, T.; Yu, F.; Long, S. “Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems” CrystEngComm 2022, 24, 681

Zhoujin, Y.; Tao, Y.; Zhou, P.; Parkin, S. R.; Li, T.; Guo, J.; Yu, F.; Long, S. “Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid” CrystEngComm, 2022, 24, 95

2021

Zhoujin, Y.; Yang, X.; Zhang, M.; Guo, J.; Parkin, S.; Li, T.; Yu, F.; Long, S. “Synthon polymorphism and π-π stacking in N-phenyl-2-hydroxynicotinanilides” Crystal Growth & Design, 2021, 21, 6155

Ren,Y.; Li, S.; Zhu, R.; Wan, C.; Song, D.; Zhu, J.; Cai, G.; Long, S.; Kong, L. Yu, W. “Discovery of STAT3 and Histone Deacetylase (HDAC) dual-pathway inhibitors for the treatment of solid cancer”，J. Med. Chem, 2021,11, 7468

Zhoujin, Y.; Zhang, M.; Parkin, S.; Li, T.; Yu, F.; Long, S. “A new solvate of clonixin and a comparison of the two clonixin solvates”, RSC Advances, 2021, 11, 24836

2020

Liu, H.; Yang, X.; Chen, J.; Zhang, M.; Parkin, S.; Cao, S.; Li, T.; Yang, Z.; Yu, F.; Long, S. “Steric effect determines the formation of lactam-lactam dimer or amide C=O...NH (lactam) chain motif in N-phenyl-2-hydroxynicotinanilides” Cryst. Growth Des. 2020, 20, 4346

Liu, H.; Yang, X.; Wu, S. Zhang, M.; Parkin, S.; Cao, S.; Li, T.; Yu, F.; Long, S. “An investigation of the polymorphism of a potent nonsteroidal anti-inflammatory drug flunixin” CrystEngComm 2020, 22, 448

Liu, H.; Long, S.; Rakesh, K. P.; Zha, G.-F. “ Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents” European Journal of Medicinal Chemistry, 2020, 185, 111804

2019

Liu, H.; Moku, B.; Li, F.; Ran, J.; Han, J.; Long, S.; Zha, G.-F.; Qin, H.-L. “Stereoselective construction of nitrile-substituted cyclopropanes from 2-substituted ethenesulfonyl fluorides via carbon-sulfur bond cleavage” Advanced Synthesis & Catalysis, 2019, 361(19), 4596

Liu, Y.; Zhang, M.; Xu, D.; Parkin, S.; Li, T.; Li, C.; Yang, Z.; Yu, F.; Long, S. “Effect of substituent size and isomerization on the polymorphism of 2-(naphthalenylamino)-benzoic acids” Crystal Growth & Design, 2019, 19(7), 3694

Zha, G.-F.; Rakesh, K. P.; Manukuma, H. M.; Shantharam, C. S.; Long, S. “Pharmaceutical significance of azepane based motifs for drug discovery: A critical review” European Journal of Medicinal Chemistry, 2019, 162, 465

學生獲獎

2014 “海普瑞杯”第四屆全國學生制藥工程研究征文比賽 二等獎 （指導教師）

2015 “海普瑞杯”第五屆全國學生制藥工程研究征文比賽 二等獎 （指導教師）

2016 第九屆藥苑論壇 三等獎 （指導教師）

2017 研究生劉夢獲第七屆全國學生制藥工程研究征文比賽 一等獎 （指導教師）

國家獎學金：2016 陳朋；2017 劉夢；2018 樂鵬雲；2019 劉浩； 2020 楊星；2021 周金韻萍；2024 崔景亮

特等學業獎學金：2018 彭思情

77779193永利官网”學術之星”：2019 樂鵬雲、彭思情

優秀畢業研究生：2018 劉夢；2019 彭思情；2020 劉浩；2022 周金韻萍；2024 陳思宇

校優秀碩士學位論文：2017 毛騰飛；2018 劉夢；2019樂鵬雲； 2020 劉浩；2021 楊星；2022 周金韻萍、陶洋、謝東；2023 趙雪、黎玉萍、董冰倩；2024 胡月潇、王靜

2020劉浩被美國南卡羅來納大學全額獎學金錄取為博士研究生

2022 周金韻萍被美國明尼蘇達大學全額獎學金錄取為博士研究生