薛亞楠，博士，副教授，碩士生導師

地址：中國.湖北.武漢.東湖新技術開發區光谷一路206号

77779193永利官网

郵編：430205

Email：xueyn_wit@163.com

電話：027-87194980

教育背景

2003 – 2009 武漢大學化學與分子科學學院，高分子化學與物理專業，博士

1999 – 2003 鄭州大學化學系，化學人才基地班，學士

工作履曆

2011至今 77779193永利官网，副教授

2009 – 2011 武漢大學生命科學學院，博士後

研究領域

生物醫用高分子材料；

靶向多功能納米材料。

承擔或參與科研項目

1. 有序平行交聯納米凝膠複合生物材料的合成，2012FFA100，湖北省自然科學基金重點項目，2012-2014，項目骨幹。

2. 還原裂解聚陽離子膠束共輸送基因和抗癌藥物研究，20100471143，中國博士後科學基金會，2010-2011，項目負責人。

3. 增溶與促透性納米給藥系統，2009CB930301，國家重大發展計劃973項目子課題，2009-2011，課題負責人。

學術成果

代表性論文：

1. Yanan Xue, Lijun Tao, Yang Zhou, Jie Liu, Bo Yu, Sihui Long, Shiwen Huang, Faquan Yu*. Enhanced targeted delivery of doxorubicin based on acid induced charge reversal and combinational stimuli-responsive nanocarrier. Advanced Engineering Materials, 2018,20(7):1701151. .

2. Yanan Xue, Xiaoyang Xia, Bo Yu, Lijun Tao, Qian Wang, Shi-Wen Huang, Faquan Yu*. Selenylsulfide bond-launched reduction-responsive superparamagnetic nanogel combined of acid-responsiveness for achievement of efficient therapy with low side effect. ACS Applied Materials & Interfaces, 2017, 9, 30253-30257.

3. Meifang Song, Yanan Xue, Xiao Lin, Xiaoyang Xia, Lidi Chen, Liujie Zhang, Bo Yu, Sihui Long, Shiwen Huang, Faquan Yu*. Achievement of release mode under combinational stimuli by acid and reduction for reduced adverse effect in antitumor efficacy. Macromolecular Materials and Engineering. 2016,301(10): 1255-1266.

4. Meifang Song, Yanan Xue, Lidi Chen, Xiaoyang Xia, Yang Zhou, Lei Liu, Bo Yu, Sihui Long, Shiwen Huang, Faquan Yu*. Acid and reduction stimulated logic “and”-type combinational release mode achieved in DOX-loaded superparamagnetic nanogel. Materials Science & Engineering C, 2016,65:354-363.

5. Han Zhang, Yanan Xue, Juan Huang, Xiaoyang Xia, Meifang Song, Kaikai Wen, Xiaoxiao Zhang, Xiaogang Luo, Ning Cai, Sihui Long, Faquan Yu*. Tailor-made magnetic nanocarriers with pH-induced charge reversal and pH-responsiveness to guide subcellular release of doxorubicin. Journal of Materials Science, 2015, 50(6): 2429-2442.

6. Lidi Chen, Yanan Xue, Xiaoyang Xia, Meifang Song, Juan Huang, Han Zhang, Bo Yu, Sihui Long, Yanping Liu, Lei Liu, Shiwen Huang, Faquan Yu*. A redox stimuli-responsive superparamagnetic nanogel with chemically anchored DOX for enhanced anticancer efficacy and low systemic adverse effect. Journal of Materials Chemistry B, 2015,3(46):8949-8962.

7. Yanan Xue, Xiaoyang Xia, Bo Yu, Xiaogang Luo, Ning Cai, Sihui Long, Faquan Yu*. A green and facile method for the preparation of a pH-responsive alginate nanogel for subcellular delivery of doxorubicin. RSC Advances, 2015, 5(90):73416-73423.

8. Juan Huang, Yanan Xue, Ning Cai, Han Zhang, Kaikai Wen, Xiaogang Luo, Sihui Long, Faquan Yu*. Efficient reduction and pH co-triggered DOX-loaded magnetic nanogel carrier using disulfide crosslinking. Materials Science & Engineering C, 2015,46:41-51.

9. 薛亞楠, 張敏, 劉磊, 李文鑫, 黃世文. 側鍊含咪唑取代基聚（L-天冬酰胺）高效基因載體研究. 高分子學報 2011;8:874-882. (SCI, IF 0.677)

10. Zhang M†, Xue YN†, Liu M, Zhuo RX, Huang SW*. Biocleavable polycationic micelles as highly efficient gene delivery vectors. Nanoscale Research Letters 2010; 5(11):1804-1811. (†co-first author) (SCI, IF 2.524)

11. Xue YN, Liu M, Peng L, Huang SW, Zhuo RX. Improving gene delivery efficiency of bioreducible poly(amidoamine)s via grafting with dendritic poly(amidoamine). Macromolecular Bioscience 2010;10(4):404-414.(SCI, IF 3.742)

12. Xue YN, Huang ZZ, Zhang JT, Liu M, Zhang M, Huang SW, Zhuo RX.Synthesis and self-assembly of amphiphilic poly (acrylic acid-b-DL-lactide) to form micelles for pH-responsive drug delivery. Polymer2009; 50(15): 3706-3713. (SCI, IF 3.379)

授權專利：

1. 一種pH響應性海藻酸鈉納米凝膠及其制備方法。 ZL2015104265218

2. 一種磁性還原響應性抗腫瘤藥物載體的制備方法。ZL201510427070X

著作：

參與編寫《化學工藝學》教材，ISSN 978-7-122-17367-6，化學工業出版社，2014年1月