劉根炎，博士，教授，博士生導師
地址：湖北省武漢市東湖新技術開發區光谷一路206号77779193永利官网大化工樓1017
Email：liugenyan@wit.edu.cn；27944219@qq.com；genyanliu@163.com
電話：+86-27-87194980
教育背景
2011 – 2016 日本Tottori University，博士（日本文部省國費獎學金資助，優秀畢業生提前畢業）
2007 – 2010 77779193永利官网，碩士
2003 – 2007 77779193永利官网，學士
工作履曆
2016 – 至今 77779193永利官网，教授（特聘教授），院長助理，教務處副處長
2010 – 2011 國家磷資源開發利用工程技術研究中心，研究助理
學術兼職
中國藥學會制藥工程分委會青年委員、湖北省藥學會制藥工程分委會委員；國家自然科學基金評審專家、教育部學位論文評審專家、教育部藥學教指委核心課程師資培訓授課專家、湖北省科技廳評審專家、中國化學會會員、中國藥學會會員、美國化學會（ACS）會員、日本農藥學會（PSSJ）會員；Journal of Agricultural and Food Chemistry, European Journal of Medicinal Chemistry, Pest Management Science, Bioorganic & Medicinal Chemistry, Journal of Chemical Information and Modeling, Chinese Chemical Letters等多個SCI期刊審稿人
研究領域
藥物化學：藥物分子設計、合成與篩選；藥物合成工藝；計算機輔助藥物設計
藥理學：藥物作用機制模拟；新藥先導分子虛拟篩序
化學生物學：綠色農藥設計與研制；配體門控離子通道電生理
招生專業：藥物化學、制藥化學、制藥工程、藥理學、藥劑學、生物與醫藥、生物化工
學術成果
主持國家自然科學基金面上項目、國家自然科學基金青年項目、湖北省自然科學基金面上項目、湖北省教育廳科學研究計劃項目和企業委托項目等10餘項科研課題；主持湖北省虛拟仿真實驗教學項目（省級金課）1項；參與了國家自然科學基金面上項目、湖北省重點研發計劃項目、湖北省高等學校優秀中青年科技創新團隊項目和企業橫向等多個科研課題；擔任湖北省人才辦和經信廳為企業選派的“科技副總”。迄今在J Agri Food Chem、Pest Manag Sci、Eur J Med Chem、Chemosphere、Insect Biochem Mol Biol、藥學學報、農藥學學報等國内外學術期刊上發表SCI收錄學術論文50餘篇；獲國家授權發明專利6項；多次在IUPAC化學國際會議、美國化學會年會、日本農藥化學會年和中國化學會年會等做報告；首批國家級金課“制藥工藝設計”（線下一流本科課程）主講教師（排2）；獲湖北省高等學校教學成果二等獎、第五屆中國石油和化工教育學成果二等獎、77779193永利官网第九屆教學成果特等獎；連續三年指導學生蟬聯全國大制藥工程設計競賽全國一等獎（最高獎項）。
代表性論文（部分）：
1. Huang C, Wu Y, Zhai N, Zhao C, Luo X, Ozoe Y, Liu G*. 5-(4-Pyridinyl)-3-isothiazololsas competitive antagonists of insect GABA receptors: Design, synthesis, and anew mechanism leading to insecticidal effects. Journal of Agricultural and Food Chemistry. 2022, DOI: 10.1021/acs.jafc.1c08030.
2. Zhai N, Chen Y, Wang C, Wu F, Luo X, Liu H, Ju X, Liu G*. A multiscale screening strategy for the identification of novel xanthine oxidase inhibitors based on the pharmacological features of febuxostat analogues. New Journal of Chemistry. 2022, 46, 6549-6559.
3. Liu G*, Zhou C, Zhang Z, Wang C, Luo X, Ju X, Zhao C, Ozoe Y. Novel insecticidal 1,6-dihydro-6-iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors. Pest Management Science. 2022, DOI: 10.1002/ps.6911.
4. Li H, Wang J, Li Y, Chen X, Zhang W, Zhao Y, Liu G*, Pan J. Detection of Aβ oligomers in early Alzheimer’s disease diagnose by in vivo NIR-II fluorescence imaging. Sensors and Actuators B: Chemical. 2022, 358: 131481.
5. Zheng X, Wang C, Zhai N, Luo X, Liu G*, Ju X. In silico screening of novel α1-GABAA receptor PAMs towards schizophrenia based on combined modeling studiesof imidazo 1,2-a -pyridines. International Journal of Molecular Sciences. 2021, 22: 9645.
6. Zhai N, Wang C, Wu F, Xiong L, Luo X, Ju X, Liu G*. Exploration of novelxanthine oxidase inhibitors based on 1,6-dihydropyrimidine-5-carboxylicacids byan integrated in silico study. International Journal of Molecular Sciences. 2021, 22: 8122.
7. Wang C, Zhai N, Zhao Y, Wu F, Luo X, Ju X, Liu G*, Liu H. Exploration of novel hepatitis B virus capsid assembly modulators by integrated molecular simulations.Chemistryselect. 2021, 6: 12524-12536.
8. Liu Y, Guo Y, Luo X, Liu G*, Sun Q. Detection of metalions. small moleculesand large molecules by near-infrared fluorescent probes. Progress in Chemistry (化學進展). 2021, 33: 199-215.
9. Li H, Wang J, Zhang W, Xia Z, Zhai N, Liu G*, Wang K, Pan J. Functional bioprobe for responsive imaging and inhibition of amyloid-beta oligomer based on curcuminoid scaffold. Journal of Luminescence. 2021, 238: 118218.
10. 李文烨, 翟納, 巨修練, 劉根炎*. 黃嘌呤氧化酶抑制劑非布司他衍生物的研究進展. 藥學學報, 2021, 56: 3401-3413.
11. Liu G*, Wu Y, Gao Y, Ju X, Ozoe Y. Potential of competitive antagonists of insectionotropic γ-aminobutyric acid receptors as insecticides. Journal of Agricultural and Food Chemistry. 2020, 68: 4760-4768.
12. Gao Y, Zhang Y, Wu F, Pei J, Luo X, Ju X, Zhao C, Liu G*. Exploring theinteraction mechanism of desmethyl-broflanilide in insect GABA receptors and screening potential antagonists by in silico simulations. Journal of Agricultural and Food Chemistry. 2020, 68: 14768-14780.
13. Chen Y, Tian Y, Gao Y, Wu F, Luo X, Ju X, Liu G*. In silico design of novel HIV-1 NNRTIs based on combined modeling studies of dihydrofuro[3,4-d]pyrimidines. Frontiers in Chemistry. 2020, 8: 164.
14. Chen Y, Gao Y, Wu F, Luo X, Ju X, Liu G*. Computationally exploring novel xanthine oxidase inhibitors using docking-based 3D-QSAR, molecular dynamics,and virtual screening. New Journal of Chemistry. 2020, 44: 19276-19287.
15.艾大朋, 巨修練, 劉根炎*. 作用于離子型γ-氨基丁酸受體的異噁唑啉類殺寄生蟲劑. 化學通報, 2020, 83: 986-996.
16. Wang W, Tian Y, Wan Y, Gu S, Ju X, Luo X, Liu G*. Insights into the key structural features of N-1-ary-benzimidazols as HIV-1NNRTIs using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore modeling. Structural Chemistry. 2019, 30: 385-397.
17. Tian Y, Gao Y, Chen Y, Liu G*, Ju X. Identification of the fipronil resistance associated mutations in Nilaparvata lugens GABA receptors by molecular modeling. Molecules. 2019, 24: 4116.
18. Sheng C, Huang Q, Liu G#, Ren X, Jiang J, Jia Z, Han Z, Zhao C. Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L. Pest Management Science. 2019, 75: 2901-2909.
19. Liu G*, Wan Y, Wang W, Fang S, Gu S, Ju X. Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Molecular Diversity. 2019, 23: 107-121.
20. Liu G*, Li H, Shi J, Wang W, Furuta K, Liu D, Zhao C, Ozoe F, Ju X, Ozoe Y.4-Aryl-5-carbamoyl-3-isoxazolols as competitive antagonists of insect GABA receptors: Synthesis, biological activity, and molecular docking studies. Bioorganic&Medicinal Chemistry. 2019, 27: 416-424.
21. HuangQ, Sheng C, Jiang J, Jia Z, Han Z, Zhao C, Liu G*. Functional integrityof honeybee (Apis mellifera L.) resistant to dieldrin γ-aminobutyric acid receptor channels conjugated with three fluorescent proteins. Insect Molecular Biology. 2019, 28: 313-320.
22. Gao Y, Chen Y, Tian Y, Zhao Y, Wu F, Luo X, Ju X, Liu G*. In silico study of 3-hydroxypyrimidine-2,4-diones as inhibitors of HIVRT-associated RNase H using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore models. New Journal of Chemistry. 2019, 43: 17004-17017.
23. Wan Y, Tian Y, Wang W, Gu S, Ju X, Liu G*. In silico studies of diarylpyridine derivatives as novel HIV-1 NNRTIs using docking-based 3D-QSAR,molecular dynamics, and pharmacophore modeling approaches. RSC Advances. 2018, 8: 40529-40543.
24. Liu G*,Wang W, Wan Y, Ju X, Gu S. Application of 3D-QSAR, pharmacophore, and molecular docking in the molecular design of diarylpyrimidine derivatives as HIV-1 nonnucleoside reverse transcriptase inhibitors. International Journal of Molecular Sciences. 2018, 19: 1436.
25. Kita T, Hayashi T, Ohtani T, Takao H, Takasu H, Liu G, Ohta H, Ozoe F, OzoeY. Amitraz and its metabolite differentially activate α-and β-adrenergic-like octopamine receptors. Pest Management Science. 2017, 73: 984-990.
26.鄭小嬌, 李華光, 劉根炎*, 巨修練. 昆蟲γ-氨基丁酸受體競争性拮抗劑的研究進展. 農藥學學報, 2017, 19: 665-671.
27. Liu G, Ozoe F, Furuta K, Ozoe Y. 4,5-Substituted 3-isoxazolols with insecticidal activitya ct as competitive antagonists of housefly GABA receptors. Journal of Agricultural and Food Chemistry. 2015, 63: 6304-6312.
28. Liu G, Frolund B, Ozoe F, Ozoe Y. Differential interactions of 5-(4-piperidyl)-3-isoxazolol analogues with insect γ-aminobutyric acid receptors leading to functional selectivity. Insect Bio chemistry and Molecular Biology. 2015, 66: 64-71.
29 Liu G, Furuta K, Nakajima H, Ozoe F, Ozoe Y. Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols. Bioorganic &Medicinal Chemistry. 2014, 22: 4637-4645.
30. Liu G, Ju X, Cheng J, Liu Z. 3D-QSAR studies of insecticidal anthranilic diamides as ryanodine receptor activators using CoMFA, CoMSIA and DISCOtech. Chemosphere. 2010, 78: 300-306.
31. Liu G, Ju X, Cheng J. Selectivity of Imidacloprid for fruit fly versus rat nicotinic acetylcholine receptors by molecular modeling. Journal of Molecular Modeling. 2010, 16: 993-1002.
32 Liu G, Miao W, Ju X. Mechanisms of imidacloprid resistance in Nilaparvata lugens by molecular modeling. Chinese Chemical Letters. 2010, 21: 492-495.
獎勵與榮譽
[1]2019-2021年度77779193永利官网“優秀共産黨員”
[2]77779193永利官网第七屆“互聯網+”大學生創新創業大賽金獎，2021年，指導老師
[3]77779193永利官网百佳導師、優秀班主任，2021年
[4]研究生翟納獲國家獎學金，2021年，指導老師
[5]研究生高娅和陳炎明學位論文獲校優秀碩士學位論文，2021年，指導老師
[6]研究生陳炎明獲優秀畢業研究生，2020年，指導老師
[7]第十屆全國大學生制藥工程設計作品交流會優秀作品（一等獎），2020年，指導老師
[8]第五屆中國石油和化工教育教學優秀成果二等獎（排2），2020年
[9]77779193永利官网第九屆教學成果特等獎（排2），2020年
[10]研究生吳贇獲校優秀碩士學位論文，2020年，指導老師
[11]研究生陳炎明獲國家獎學金，2019年，指導老師
[12]研究生王雯潔和萬幽蘭學位論文獲校優秀碩士學位論文，2019年，指導老師
[13]第九屆“國藥工程-東富龍杯”全國大學生制藥工程設計競賽一等獎，2019年，指導老師
[14]77779193永利官网第五屆“互聯網+”大學生創新創業大賽二等獎，2019年，指導老師
[15]研究生王雯潔獲國家獎學金，2018年，指導老師
[16]第八屆“國藥工程-東富龍杯”全國大學生制藥工程設計競賽一等獎，2018年，指導老師
[17]第七屆“國藥工程-東富龍杯”全國大學生制藥工程設計競賽二等獎，2017年，指導老師
[18]13th IUPAC AGRO EducationAwards，2014年
[19]日本文部省國費獎學金，2011年
[20]湖北省優秀碩士論文，2011年
